| MMP9 | |
|---|---|
| Matrix Metalloproteinase-9 / Gelatinase B | |
| Protein Name | Matrix Metalloproteinase-9 |
| Gene | MMP9 |
| UniProt ID | P14780 |
| PDB IDs | 1GKC, 1ITV, 2OW1, 5TH6 |
| Molecular Weight | 92 kDa (proenzyme), 82 kDa (active) |
| Subcellular Localization | Extracellular, secreted |
| Protein Family | Metzincin superfamily, Matrix metalloproteinase family |
Mmp9 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
MMP9 (Matrix Metalloproteinase-9), also known as gelatinase B, is a zinc-dependent endopeptidase that degrades extracellular matrix proteins. It plays important roles in tissue remodeling, inflammation, and neural plasticity. MMP9 is implicated in various neurodegenerative diseases.
MMP9 has a characteristic MMP domain structure:
MMP9 is upregulated in AD brain and contributes to:
MMP9 may contribute to PD through:
MMP9 is highly upregulated after stroke and contributes to:
MMP9 is a therapeutic target for various conditions:
The study of Mmp9 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.