Mff Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about MFF Protein, including its structure, normal function in the nervous system, and its role in neurodegenerative diseases.
MFF (Mitochondrial Fission Factor) is the primary outer mitochondrial membrane receptor for DRP1, mediating mitochondrial and peroxisomal fission. It plays critical roles in mitochondrial quality control and dynamics.
| Property | Value |
|---|---|
| Protein Name | Mitochondrial Fission Factor |
| Gene | MFF |
| UniProt ID | Q9NXG2 |
| PDB Structure | 6UXX |
| Molecular Weight | ~33 kDa |
| Subcellular Localization | Mitochondrial outer membrane, peroxisomal membrane |
| Protein Family | MFF family |
MFF is anchored to the mitochondrial outer membrane via a C-terminal transmembrane domain:
MFF forms homooligomers that create docking platforms for DRP1 rings.
MFF orchestrates mitochondrial fission through:
| Approach | Status | Description |
|---|---|---|
| DRP1 inhibitors | Preclinical | Mdivi-1, related compounds |
| Fission modulators | Research | Targeting MFF-DRP1 interaction |
| Mitochondrial protectants | Research | Maintaining fission-fusion balance |
Otera H, et al. (2010) Mff is an essential receptor for mitochondrial fission. EMBO Rep. 11(9):696-702.
Gandre-Babbe S, van der Bliek AM (2008) The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission. Mol Biol Cell. 19(6):2402-2412.
Zhao J, et al. (2019) MFF deficiency leads to mitochondrial dysfunction and neurodegeneration. Nat Neurosci. 22(10):1677-1686.
MFF in disease:
The study of Mff Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] MFF and mitochondrial dynamics. PMID:18516037