MAO-A is a protein that mao-a catalyzes the oxidative deamination of:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
Monoamine oxidase A (MAO-A) is a mitochondrial enzyme that catalyzes the oxidative deamination of monoamine neurotransmitters, including serotonin, norepinephrine, and dopamine. It is a key regulator of monoamine levels in the brain and is critically involved in mood regulation, aggression, and neurodegenerative processes.
MAO-A is a flavin adenine dinucleotide (FAD)-dependent enzyme anchored to the outer mitochondrial membrane.
| Property | Value |
|---|---|
| Gene | MAOA |
| UniProt | P21397 |
| Molecular Weight | ~59 kDa (527 amino acids) |
| Subcellular Localization | Outer mitochondrial membrane |
| Tissue Expression | Brain (neurons, astrocytes), peripheral tissues |
MAO-A catalyzes the oxidative deamination of:
The reaction produces hydrogen peroxide as a byproduct, which can contribute to oxidative stress if not properly managed.
| Drug | Type | Clinical Use |
|---|---|---|
| Phenelzine | Irreversible | Depression, PTSD |
| Tranylcypromine | Irreversible | Depression |
| Moclobemide | Reversible | Depression |
| Brofaromine | Reversible | Depression (discontinued) |