LSM1 (LSM1 Homolog, mRNA Surveillance Complex) is an RNA-binding protein belonging to the Sm-like family. LSM1 forms ring-shaped heptameric complexes that bind to RNA molecules and participate in various aspects of RNA metabolism, including mRNA decapping, splicing, and decay.
| Attribute |
Value |
| Protein Name |
LSM1 Homolog |
| Gene |
LSM1 |
| UniProt ID |
Q9Y4Z0 |
| Molecular Weight |
~15 kDa |
| Structure |
Ring-shaped heptamer |
| Subcellular Localization |
Nucleus, Cytoplasm, Stress granules |
LSM1 proteins form ring-shaped complexes:
- Seven subunits arranged in a torus
- Bind to single-stranded RNA
- Associate with snRNAs and mRNAs
- Part of the LSM1-7 complex involved in mRNA decapping
- Regulates mRNA stability and turnover
- Participates in spliceosome assembly
- Localizes to stress granules under stress conditions
- Involved in mRNA triage during cellular stress
- LSM1 affects TDP-43 pathology
- Dysregulated RNA processing contributes to neurodegeneration
- Altered RNA metabolism in tauopathies
- LSM1 dysfunction may affect neuronal gene expression
- LSM1 overexpression promotes tumor progression
RNA metabolism proteins represent potential targets for:
- Modulating TDP-43 pathology
- Enhancing neuronal RNA processing
- LSM complexes in RNA metabolism (2019)
- RNA processing in neurodegeneration (2018)
- TDP-43 and stress granules (2017)
- Tharun et al., LSM complexes in RNA metabolism (2009)
- NCBI Gene: LSM1
- UniProt: LSM1
- OMIM: LSM1
- Kadie et al., LSM1 in viral replication (2018)
- GeneCards: LSM1
- Fromont-Racine et al., LSM in snRNP biogenesis (2003)
- Beggs et al., LSM family functions (2005)