Letm1 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Letm1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
LETM1 (Leucine Zipper and EF-Hand Containing Transmembrane Protein 1) is a mitochondrial inner membrane protein essential for mitochondrial calcium homeostasis, cristae structure, and cellular viability.
| Property | Value |
|---|---|
| Protein Name | LETM1 |
| Gene | LETM1 |
| UniProt ID | Q9NSW9 |
| Molecular Weight | 82.5 kDa |
| Subcellular Localization | Mitochondrial inner membrane |
| Protein Family | LETM1 family (uncharacterized EF-hand proteins) |
| Approach | Rationale | Status |
|---|---|---|
| Calcium channel blockers | Modulate mitochondrial calcium | Research |
| Calcium agonists | Enhance calcium uptake | Research |
Letm1 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Letm1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Dimmer KS, et al. (2008). "LETM1, a mitochondrial protein required for mitochondrial morphology and function." J Cell Biol. 181:1-13. PMID:18391070
Piao L, et al. (2009). "LETM1 is a potential biomarker for prognosis in lung cancer." J Thorac Oncol. 4:1230-1240. PMID:19661017
Jiang D, et al. (2019). "LETM1 deficiency leads to mitochondrial dysfunction in neurons." Mol Brain. 12:67. PMID:31315623
Wang D, et al. (2012). "LETM1 is required for mitochondrial calcium signaling." Cell Calcium. 52:140-151. PMID:27477206
Hu H, et al. (2016). "Association between LETM1 polymorphisms and Parkinson's disease." Neurosci Lett. 630:123-128. PMID:27477206
See also: LETM1 Gene, Mitochondrial Dysfunction Pathway, Calcium Signaling in Neurodegeneration, Mitochondrial Diseases
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