| LAMP2A | |
|---|---|
| Lysosomal-Associated Membrane Protein 2A | |
| Protein Name | Lysosomal-Associated Membrane Protein 2A |
| Gene | LAMP2 |
| UniProt ID | P13473 |
| PDB IDs | 5MYI, 5MZV, 6E10 |
| Molecular Weight | ~45 kDa (after processing) |
| Subcellular Localization | Lysosomal membrane |
| Protein Family | LAMP family |
Lamp2A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
LAMP2A is the lysosomal receptor for chaperone-mediated autophagy (CMA), a selective autophagy pathway that degrades specific cytosolic proteins in lysosomes. It is crucial for cellular protein quality control and is implicated in neurodegenerative diseases.
LAMP2A is a type I membrane glycoprotein:
The protein forms multimeric complexes in the lysosomal membrane to create the CMA translocation channel.
CMA is a selective autophagy pathway:
LAMP2A dysfunction contributes to PD pathogenesis:
LAMP2A deficiency in AD:
LAMP2 mutations cause Danon disease:
LAMP2A activation is being explored as therapy:
The study of Lamp2A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.