Kif7 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{infobox .infobox-protein}}
| Property | Value |
|---|---|
| Protein Name | Kinesin Family Member 7 |
| Gene | KIF7 |
| UniProt ID | Q2V4R5 |
| Molecular Weight | ~200 kDa |
| Subcellular Localization | Cilia, axonemes, centrosome |
| Protein Family |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
| Kinesin-13 family |
| Expression | Brain, ciliated tissues |
KIF7 is a kinesin-13 family member with a characteristic central catalytic domain. Unlike other kinesins, kinesin-13 family members do not walk along microtubules but instead depolymerize them from ends. KIF7 contains an N-terminal motor domain, a coiled-coil region, and a C-terminal cargo-binding domain [1].
KIF7 localizes to the base of primary cilia and regulates Hedgehog (Hh) signaling pathway components [2].
Ciliary Function: Regulates cilia assembly and disassembly through microtubule depolymerization
Hedgehog Signaling: Modulates Hedgehog pathway activity by transporting GLI proteins
Brain Development: Essential for proper morphogenesis during neural tube development
Axon Guidance: Controls growth cone responsiveness to guidance cues
Cell Cycle Regulation: Involved in mitotic spindle dynamics
The study of Kif7 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.