Kif5C Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Kif5C Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Protein Name: Kinesin-1 Heavy Chain (Neuronal)
Gene: KIF5C
UniProt ID: Q9P0N2
PDB ID: 6RMX
Molecular Weight: 109 kDa (heavy chain)
Subcellular Localization: Axons, Dendrites, Cytoplasm
Protein Family: Kinesin-1 family (Kinesin II)
KIF5C has a distinctive structure adapted for its function:
KIF5C is a neuron-specific kinesin heavy chain that forms functional kinesin-1 motors with KIF5B. It mediates anterograde axonal transport of organelles, synaptic vesicle precursors, mitochondria, and signaling complexes. KIF5C is essential for neuronal connectivity and synaptic function.
Mutations in KIF5C cause intellectual disability and cortical malformations. KIF5C is implicated in Alzheimer's and Parkinson's disease where transport defects contribute to pathology.
KIF5C represents a potential therapeutic target:
Kif5C Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Kif5C Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.