Kif20A Protein (Kinesin Family Member 20A) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-protein
| KIF20A Protein (Kinesin Family Member 20A) | |
|---|---|
| Gene | KIF20A |
| UniProt | Q9H8Y8 |
| Molecular Weight | ~76 kDa |
| Subcellular Localization | Golgi apparatus, cytoplasm |
| Protein Family | Kinesin family |
| Aliases | MKLP2, RAB6KIFL |
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KIF20A (also known as MKLP2) is a member of the kinesin-6 subfamily. It is a plus-end-directed motor protein involved in intracellular transport and cell division. The protein contains an N-terminal motor domain and a C-terminal coiled-coil region for cargo binding.
KIF20A participates in:
KIF20A is overexpressed in multiple cancers:
KIF20A may play a role in neuronal survival:
KIF20A is a potential therapeutic target in cancer:
The study of Kif20A Protein (Kinesin Family Member 20A) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The KIF20A Protein is a protein involved in various cellular processes in the nervous system. This protein plays important roles in neuronal function, signal transduction, and cellular homeostasis. Dysfunction of this protein has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
The KIF20A Protein participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to synaptic transmission, membrane potential regulation, and intracellular signaling cascades.
Alterations in KIF20A Protein expression or function have been associated with several neurodegenerative conditions. Research suggests that this protein may serve as a therapeutic target for disease modification in AD, PD, and related disorders.