Kif13B Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{infobox .infobox-protein}}
| Property | Value |
|---|---|
| Protein Name | Kinesin Family Member 13B |
| Gene | KIF13B |
| UniProt ID | Q9NPL8 |
| Molecular Weight | ~180 kDa |
| Subcellular Localization | Neuronal axons, dendrites, growth cones |
| Protein Family | Kinesin |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
-13 family |
| Expression | Brain, high in hippocampus and cortex |
KIF13B is a member of the kinesin-13 family, characterized by a central catalytic domain that depolymerizes microtubules rather than walking along them. The protein contains an N-terminal motor domain with ATP-dependent microtubule depolymerization activity and a C-terminal tail that mediates cargo binding [1].
KIF13B localizes to the leading edge of migrating cells and neuronal growth cones, where it regulates microtubule dynamics [2].
Microtubule Dynamics Regulation: Depolymerizes microtubules at specific cellular locations, regulating growth cone steering and cell migration [3]
Axon Guidance: Controls growth cone dynamics during neural development by modulating microtubule stability
Synaptic Plasticity: Regulates spine morphology and synaptic plasticity through microtubule remodeling
Membrane Trafficking: Associates with endocytic vesicles and regulates endosomal trafficking
Neuronal Polarity: Contributes to axon-dendrite specification through localized microtubule remodeling
The study of Kif13B Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.