Kat2B Protein — Lysine Acetyltransferase 2B (Pcaf) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| KAT2B Protein | |
|---|---|
| Protein Name | Lysine Acetyltransferase 2B (PCAF) |
| Gene | KAT2B |
| UniProt ID | Q92830 |
| Molecular Weight | 93 kDa |
| Subcellular Localization | Nucleus |
| Protein Family | GNAT family (Gcn5-related N-acetyltransferases) |
KAT2B (also known as PCAF) contains an N-terminal bromodomain that recognizes acetylated lysines, a catalytic HAT domain, and a PHD finger that mediates protein-protein interactions. The bromodomain allows KAT2B to bind to chromatin marks and target its enzymatic activity.
KAT2B is a histone acetyltransferase that primarily acetylates histone H3 (particularly on lysine 14) and histone H4. It functions as a transcriptional coactivator by:
In the nervous system, KAT2B plays crucial roles in:
Dysregulation of KAT2B has been implicated in:
The study of Kat2B Protein — Lysine Acetyltransferase 2B (Pcaf) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The KAT2B Protein is involved in various cellular processes in the nervous system. This protein plays important roles in neuronal function, ion channel regulation, and cellular homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
The KAT2B Protein participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to synaptic transmission, membrane potential regulation, and intracellular signaling.
Alterations in KAT2B Protein expression or function have been associated with several neurodegenerative conditions. Research suggests this protein may serve as a therapeutic target for disease modification.