Idh1 Protein Isocitrate Dehydrogenase 1 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Idh1 Protein Isocitrate Dehydrogenase 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
IDH1 (Isocitrate Dehydrogenase 1) is a cytosolic enzyme that catalyzes the NADP+-dependent conversion of isocitrate to α-ketoglutarate, producing NADPH.
| Property | Value |
|---|---|
| Gene | IDH1 |
| UniProt ID | O75874 |
| Molecular Weight | ~47 kDa |
| Structure | Homodimer |
| Localization | Cytosol, Peroxisomes |
IDH1 forms homodimers with each subunit consisting of:
The active site contains the substrate binding pocket for isocitrate.
Idh1 Protein Isocitrate Dehydrogenase 1 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Idh1 Protein Isocitrate Dehydrogenase 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.