Hnrnpa2B1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Heterogeneous Nuclear Ribonucleoprotein A2/B1
| Protein Name | HNRNPA2B1 (hRNPA2/B1) |
|---|---|
| Gene | HNRNPA2B1 |
| UniProt ID | P22626 |
| PDB ID | 1U6N, 2M5G |
| Molecular Weight | 37 kDa |
| Subcellular Localization | Nucleus, cytoplasm (shuttles) |
| Protein Family | hnRNP A/B family |
HNRNPA2B1 PROTEIN is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of HNRNPA2B1 PROTEIN is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
HNRNPA2B1 contains multiple functional domains:
HNRNPA2B1 is an RNA-binding protein critical for RNA metabolism:
Pathogenic HNRNPA2B1 mutations cause:
The study of Hnrnpa2B1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.