Hdac6 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Hdac6 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The HDAC6 gene (Histone Deacetylase 6) encodes a unique cytoplasmic histone deacetylase with key roles in protein quality control, autophagy, and cytoskeletal regulation. HDAC6 is a promising therapeutic target for neurodegenerative diseases.
| Attribute | Value |
|---|---|
| Protein Symbol | HDAC6 |
| Full Name | Histone Deacetylase 6 |
| NCBI Protein ID | NP_006035.2 |
| UniProt ID | Q9UBN7 |
| Molecular Weight | 131 kDa |
| Amino Acids | 1215 |
HDAC6 is a unique HDAC isoform:
HDAC6 contains unique features:
| Domain | Function |
|---|---|
| N-terminal | DDC1 motif, zinc finger |
| Catalytic domain 1 | Deacetylase activity |
| Catalytic domain 2 | Deacetylase activity |
| C-terminal | HSP90 binding |
HDAC6 deacetylates key substrates:
HDAC6 regulates aggrephagy:
HDAC6 expression in brain:
| Cell Type | Expression | Notes |
|---|---|---|
| Neurons | High | Synaptic function |
| Astrocytes | Moderate | Stress response |
| Microglia | Moderate | Immune function |
| Oligodendrocytes | Low | Myelin function |
High expression in hippocampus and cortex.
HDAC6 as drug target:
| Strategy | Approach | Status |
|---|---|---|
| Inhibitors | Tubastatin A, ACY-1215 | Preclinical/clinical |
| Gene therapy | siRNA-mediated knockdown | Research |
| Modulators | Allosteric modulators | Early stage |
Benefits of HDAC6 inhibition:
Key findings from models:
Current research focus:
Hdac6 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Hdac6 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Hubbert C, et al. HDAC6 is a cytoplasmic deacetylase. Nature. 2002;417(6887):455-458. PMID:12024216
Matsuyama A, et al. In vivo destabilization of HDAC6. Nat Cell Biol. 2004;6(9):844-851. PMID:15311282
Pandey UB, et al. HDAC6 and aggresome formation. Autophagy. 2007;3(4):316-320. PMID:17568179
Simões-Pires CA, et al. HDAC6 as a target for neurodegenerative diseases. Curr Med Chem. 2013;20(12):1581-1589. PMID:23410167
Chen L, et al. HDAC6 and neurodegeneration. Neurobiol Dis. 2020;138:104785. PMID:32028017