Mglur2 Protein — Glutamate Metabotropic Receptor 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
mGluR2 (Metabotropic Glutamate Receptor 2) is a G protein-coupled receptor that negatively regulates glutamate release and modulates synaptic transmission in the central nervous system.
| Attribute | Value |
|---|---|
| Protein Name | Metabotropic Glutamate Receptor 2 |
| Gene | GRM2 |
| UniProt ID | Q14416 |
| PDB ID | 7LDN, 7EVO |
| Molecular Weight | ~95 kDa (872 aa) |
| Subcellular Localization | Presynaptic membrane, postsynaptic density |
| Protein Family | Class C GPCR, mGluR family |
mGluR2 has the typical Class C GPCR structure:
| Drug | Mechanism | Status | Indication |
|---|---|---|---|
| LY341495 | mGluR2/3 antagonist | Research tool | - |
| DCG-IV | mGluR2 agonist | Research tool | Neuroprotection |
| Pomaglumetad | mGluR2/3 agonist | Clinical trials | Schizophrenia |
mGluR2 is predominantly expressed in brain regions associated with glutamate neurotransmission:
mGluR2 shows high conservation across mammals, with >95% sequence homology between human and rodent orthologs.
The study of Mglur2 Protein — Glutamate Metabotropic Receptor 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Conn, P. J., et al. (2009). Pharmacology and functions of metabotropic glutamate receptors. Annual Review of Pharmacology and Toxicology, 49, 1-32. PMID:18928405
[2] Nicoletti, F., et al. (2011). Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology, 60(7-8), 1017-1041. PMID:20950656
[3] Schoepp, D. D. (2001). Unveiling the functions of presynaptic metabotropic glutamate receptors. Journal of Pharmacology and Experimental Therapeutics, 299(1), 12-20. PMID:11660915
[4] Moghaddam, B., & Adams, B. W. (1998). Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science, 281(5381), 1349-1352. PMID:9733508
[5] Cartmell, J., & Schoepp, D. D. (2000). Regulation of neurotransmitter release by metabotropic glutamate receptors. Journal of Neurochemistry, 75(3), 889-907. PMID:10936169
[1] Conn PJ, et al. Metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol. 2000.
[2] Nicoletti F, et al. Metabotropic glutamate receptors. Neuropharmacology. 2011.
[3] Cleva RM, et al. mGluR2/3 and mGluR5 in Parkinson's disease. Neuropharmacology. 2011.
[4] Austin PJ, et al. mGluR2 receptors in neurodegenerative disease. J Neurochem. 2014.
[5] Liu J, et al. mGluR2 in Alzheimer's disease. Front Cell Neurosci. 2016.