Gpx4 (Glutathione Peroxidase 4) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| GPX4 (Glutathione Peroxidase 4) | |
|---|---|
| Protein Name | Glutathione Peroxidase 4 |
| Gene | GPX4 |
| UniProt | P36969 |
| PDB ID | 2OBI, 5OZV |
| Molecular Weight | 19 kDa |
| Localization | Cytosol, Membrane, Mitochondria |
| Protein Family | Selenoprotein family |
GPX4 (Glutathione Peroxidase 4) is a unique selenoprotein that reduces phospholipid hydroperoxides, making it crucial for preventing lipid peroxidation and ferroptosis. Unlike other GPX family members, GPX4 can directly reduce lipid peroxides in membranes.
GPX4:
GPX4:
Alzheimer's Disease: GPX4 expression is altered in AD brain. The enzyme may protect against amyloid-beta toxicity.
Parkinson's Disease: GPX4 may protect dopaminergic neurons from oxidative damage.
ALS: GPX4 is implicated in motor neuron survival.
Stroke: GPX4 is neuroprotective in ischemic injury.
The study of Gpx4 (Glutathione Peroxidase 4) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.