Fumarate Hydratase Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Fumarate Hydratase Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Fumarate Hydratase Protein
| Protein Name | Fumarate Hydratase Protein |
| Gene | FH |
| UniProt ID | P07954 |
| PDB IDs | 1EAK, 1F2P |
| Molecular Weight | 50 kDa |
| Subcellular Localization | Mitochondrial Matrix |
| Protein Family | Fumarate Hydratase Family |
FH protein belongs to the Fumarate Hydratase Family. The protein localizes to Mitochondrial Matrix.
FH catalyzes the reversible hydration of fumarate to malate in the Krebs cycle. In mitochondria, it plays a critical role in maintaining proper carbon flux through the cycle.
FH loss-of-function leads to hereditary leiomyomatosis and renal cell cancer (HLRCC). Accumulated fumarate inhibits α-ketoglutarate-dependent dioxygenases, causing epigenetic dysregulation and pseudohypoxia relevant to neurodegeneration.
Erythropoietin and bevacizumab have been used in HLRCC; no specific neuroprotective treatments.
Fumarate Hydratase Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Fumarate Hydratase Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.