| FGF1 — Acidic Fibroblast Growth Factor | |
|---|---|
| Protein Name | FGF1 (aFGF) |
| Gene | FGF1 |
| UniProt ID | P05230 |
| Molecular Weight | ~17 kDa (155 amino acids) |
| Subcellular Localization | Cytoplasm, Extracellular space |
| Protein Family | FGF (Fibroblast Growth Factor) family |
| Structure | Beta-trefoil fold |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Stroke |
FGF1 (Acidic Fibroblast Growth Factor), also known as aFGF, is a member of the FGF family of growth factors. Encoded by the FGF1 gene, this protein is a potent neurotrophic factor that promotes neuronal survival, proliferation, and differentiation in the central and peripheral nervous systems [1][2].
FGF1 was the first growth factor of the FGF family to be characterized and remains one of the most studied neurotrophic factors for its potential therapeutic applications in neurodegenerative diseases [3].
FGF1 adopts a distinctive beta-trefoil structure consisting of:
Heparin-Binding Domain
Receptor-Binding Sites
FGF1 activates multiple FGFR isoforms:
Upon FGFR activation:
FGF1 in AD:
Neuroprotection
Neurogenesis
In PD:
FGF1 therapeutics:
Burgess et al., The structure of fibroblast growth factor (1990). Cell, 1990.
Ornitz et al., Fibroblast growth factors (2015). Genes & Development, 2015.
Beenken et al., The FGF family of growth factors (2009). Trends in Neurosciences, 2009.
Zhao et al., FGF1 and FGFR in Alzheimer's disease (2021). Journal of Alzheimer's Disease, 2021.
FGF1 UniProt Entry P05230. UniProt, 2024.