Elongator Complex Subunit 1 (Ikbkap) Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Elongator Complex Subunit 1 (IKBKAP) |
| Gene | ELP1 |
| UniProt ID | Q9Y5Q3 |
| PDB ID | 6O0S, 6O0T |
| Molecular Weight | 140 kDa |
| Subcellular Localization | Cytoplasm, Nucleus |
| Protein Family | Elongator complex |
Elongator Complex Subunit 1 (ELP1), also known as IKBKAP (IKK complex-associated protein), is a scaffolding protein that is part of the Elongator complex. This complex is involved in transcription elongation through histone acetylation and tRNA modification.
Hereditary Sensory and Autonomic Neuropathy Type I (HSAN1):
Amyotrophic Lateral Sclerosis:
Alzheimer's Disease:
The study of Elongator Complex Subunit 1 (Ikbkap) Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.