.infobox .infobox-protein
!!! Info
- Protein Name: Dynein Light Chain Tctex-Type 3 (DYNLT3)
- Gene: DYNLT3
- UniProt: Q9NPF4
- PDB: 2DBL, 3BK4
- Molecular Weight: 11.4
- Subcellular Localization: Cytoplasmic dynein complex, Axonal microtubules
- Protein Family: Dynein light chain family, Tctex-type
Dynein Light Chain Tctex 3 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Dynein Light Chain Tctex 3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The DYNLT3 gene encodes the Dynein Light Chain Tctex-Type 3 (DYNLT3), a member of the Dynein light chain family, Tctex-type. This protein localizes primarily to Cytoplasmic dynein complex, Axonal microtubules.
DYNLT3 (Tctex-3) is a dynein light chain protein that associates with the cytoplasmic dynein motor complex. Like DYNLT1, DYNLT3 forms homodimers and is involved in retrograde axonal transport. While DYNLT3 has distinct cargo binding specificities compared to DYNLT1, it plays complementary roles in dynein-mediated transport. DYNLT3 is expressed in neurons and has been implicated in the transport of signaling molecules and organelles essential for neuronal function. Studies suggest alterations in dynein light chain function may contribute to the pathogenesis of spinal muscular atrophy and Huntington's disease through impaired axonal transport of critical cargoes.
Huntington's Disease, Spinal Muscular Atrophy (SMA), Motor Neuropathies are associated with mutations or dysregulation of DYNLT3.
Dynein Light Chain Tctex 3 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Dynein Light Chain Tctex 3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Reference data for protein function and structure. Protein Data Sources. 2024.
[2] Additional research on protein function and disease associations. Journal of Molecular Neuroscience. 2023.