Dynamin 1 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Dynamin 1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Dynamin-1 |
| Gene | DNM1 |
| UniProt ID | Q05193 |
| PDB Structures | 1XNX, 2X3E, 3ZYL |
| Molecular Weight | 96 kDa |
| Subcellular Localization | Presynaptic Terminal, Cytoplasm |
| Protein Family | Dynamin family |
Dynamin-1 is a 864 amino acid GTPase with a GTPase domain, middle domain, GTPase effector domain (GED), and proline-rich domain (PRD). The PRD interacts with SH3 domain-containing proteins including amphiphysin and endophilins. Dynamin-1 assembles into helical oligomers around vesicle necks, and GTP hydrolysis drives membrane scission.
Dynamin-1 is essential for:
Dynamin-1 is phosphorylated by CDK5 and dephosphorylated by calcineurin in response to synaptic activity.
Dynamin-1 dysfunction contributes to:
Dynamin 1 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Dynamin 1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.