Dishevelled 3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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| Protein Name |
Dishevelled 3 |
| Gene |
DVL3 |
| UniProt ID |
Q9NP99 |
| PDB ID |
4WJI, 4WJJ, 4WJK |
| Molecular Weight |
75-80 kDa |
| Subcellular Localization |
Cytoplasm, Cell membrane, Synapses |
| Protein Family |
Dishevelled family |
Dishevelled 3 (DVL3) is the third member of the dishevelled protein family, with highest expression in neuronal tissues. It plays unique roles in brain development and function while sharing redundancy with DVL1 and DVL2.
- Size: 716 amino acids
- Molecular weight: ~75-80 kDa
- Domains: DAX, PDZ, and DEP domains
- Neuronal enrichment: Higher expression in brain compared to other DVLs
- Wnt signaling: Transduces both canonical and non-canonical Wnt signals
- Synaptic function: Localizes to synapses, regulates dendritic arborization
- Neuronal migration: Important for neuronal positioning during development
- Axon guidance: Mediates Wnt-dependent guidance cues
Alzheimer's Disease:
- DVL3 in synaptic dysfunction
- Wnt signaling neuroprotection impaired
Parkinson's Disease:
- Essential for dopaminergic neuron maintenance
- Altered expression in PD models
Autism Spectrum Disorder:
- DVL3 variants associated with ASD
- Affects synaptic development
- Etheredge et al. (2019). "Dvl3 regulates neuronal migration." Development. PMID: 31000581
- Varela-Nallar et al. (2015). "Wnt signaling in Alzheimer's disease." J Alzheimers Dis. PMID: 25550225
The study of Dishevelled 3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Dishevelled-3 in Wnt signaling and development (2019)
- DVL3 in neuronal migration and patterning (2018)
- Dishevelled-3 in dopaminergic neuron development (2020)
- DVL3 mutations and neurodevelopmental phenotypes (2019)
- Wnt3a/Dvl3 signaling in midbrain formation (2017)
- Dishevelled-3 in synaptic transmission (2021)
- DVL3 and neuropsychiatric disorders (2020)
- Wnt signaling therapeutic potential in PD (2022)