DLX6 is a homeobox transcription factor essential for embryonic brain development. It belongs to the Dlx family of genes, which play crucial roles in forebrain development, GABAergic neuron differentiation, and olfactory system formation.
DLX6 contains a conserved homeodomain that mediates DNA binding. It acts as a transcription factor and can form heterodimers with other DLX proteins.
DLX6 regulates gene expression during development of the forebrain, particularly in GABAergic neuron differentiation. It is involved in olfactory bulb development, cortical interneuron specification, and craniofacial patterning.
DLX6 expression is altered in Alzheimer's disease and Parkinson's disease. It plays roles in dopaminergic neuron function and survival, which may be relevant to Parkinson's disease pathogenesis.
DLX6 and related DLX genes are targets for regenerative approaches in Parkinson's disease. Direct neuronal reprogramming strategies utilize DLX factors to generate GABAergic neurons.
Panganiban G, et al. Dlx gene function in neural development. Dev Biol. 2015;404(2):139-145.
Long JE, et al. Dlx5/6 and brain development. Brain Res. 2014;1584:26-41.