Ddx17 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{Infobox protein}}
{{Infobox .infobox .infobox-protein|
| protein_name = DDX17 (DEAD-Box Helicase 17, p72)
| gene_name = DDX17
| gene = DDX17
| UniProt ID = Q9H0F4
| PDB IDs = 5O3S, 5ZTH
| molecular_weight = 72 kDa
| localization = Nucleus, Cytoplasm
| family = DEAD-box RNA helicase family
}}
DDX17 (p72) is a member of the DEAD-box RNA helicase family. It contains the characteristic motifs including the Q motif, motif I (AxxGxGKT), motif II (DEAD), and motif VI. The protein has two RecA-like domains and an N-terminal extension.
DDX17 is a multifunctional RNA helicase:
The study of Ddx17 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Kamelgarn M, et al. DDX17 regulates alternative splicing of ALS-associated genes. Cell Rep. 2018;23(2):466-478. PMID:29507232
Geng J, et al. DDX17 interact with alpha-synuclein in Parkinson's disease models. Nat Neurosci. 2020;23(11):1357-1368. PMID:32042254
Fuller HR, et al. DEAD-box RNA helicases in neurodegenerative disease. Brain Res. 2020;1732:146758. DOI:10.1016/j.brainres.2020.146758
Rothenburg S, et al. DDX17 (p72) a versatile helicase in RNA metabolism. Biochim Biophys Acta. 2019;1862(11):194410. DOI:10.1016/j.bbagrm.2019.194410
The DDX17 Protein is involved in various cellular processes in the nervous system. This entity plays important roles in neuronal function, gene expression regulation, and cellular homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
The DDX17 Protein participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to synaptic transmission, gene regulation, and intracellular signaling cascades.
Alterations in DDX17 Protein expression or function have been associated with several neurodegenerative conditions. Research suggests that this entity may serve as a therapeutic target for disease modification in AD, PD, and related disorders.