Cyp46A1 Protein — Cholesterol 24 Hydroxylase (Cyp46A1) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Cyp46A1 Protein — Cholesterol 24 Hydroxylase (Cyp46A1) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Cholesterol 24-hydroxylase (CYP46A1) is a neuron-specific cytochrome P450 enzyme that catalyzes the conversion of cholesterol to 24(S)-hydroxycholesterol. This enzyme is the primary mechanism for cholesterol elimination from the brain, as 24-hydroxycholesterol can cross the blood-brain barrier. CYP46A1 expression is regulated by the nuclear receptor LXR and is essential for maintaining brain cholesterol homeostasis. Genetic variations in CYP46A1 have been associated with increased Alzheimer's disease risk, and the enzyme is considered a promising therapeutic target.
| CYP46A1 | |
|---|---|
| Protein Name | Cholesterol 24-Hydroxylase (CYP46A1) |
| Gene | CYP46A1 |
| UniProt ID | Q9Y3D5 |
| PDB IDs | 5X29, 5UVW |
| Molecular Weight | 56 kDa |
| Subcellular Location | Endoplasmic Reticulum, Neurons |
| Protein Family | Cytochrome P450 family |
CYP46A1 is central to maintaining cholesterol homeostasis:
CYP46A1:
HMGCR:
SREBP-2:
Elevated brain cholesterol is associated with increased Aβ production:
| Target | Approach | Status |
|---|---|---|
| CYP46A1 | Activation | Preclinical |
| HMGCR | Statins | Clinical trials |
| SREBP-2 | Modulation | Research |
Cyp46A1 Protein — Cholesterol 24 Hydroxylase (Cyp46A1) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Cyp46A1 Protein — Cholesterol 24 Hydroxylase (Cyp46A1) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Bjorkhem I, et al. (2006). "Cholesterol 24-hydroxylase: an enzyme of cholesterol elimination in the brain." Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2006.02.114
Carter CJ. (2007). "Alzheimer's disease: APP, gamma-secretase, APOE, LDLR, and cholesterol: a pathological triad?" Journal of Neurochemistry. DOI:10.1111/j.1471-4159.2007.04586.x