| CYFIP2 | |
|---|---|
| Gene | CYFIP2 |
| UniProt | Q9Y2D89 |
| PDB | N/A |
| Mol. Weight | 125 kDa |
| Localization | Cytoplasm |
| Family | FMRP interacting protein family |
| Diseases | Intellectual Disability, Neurodevelopmental Disorders |
Cyfip2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CYFIP2 is a protein encoded by the CYFIP2 gene. It belongs to the FMRP interacting protein family family and has a molecular weight of approximately 125 kDa. This protein is localized to Cytoplasm and plays a significant role in the pathogenesis of Intellectual Disability, Neurodevelopmental Disorders.
CYFIP2 has been characterized structurally through X-ray crystallography and cryo-EM. Available PDB structures include: No structures deposited.
The protein's three-dimensional structure can also be explored via the AlphaFold Protein Structure Database.
Under physiological conditions, CYFIP2 performs essential functions in the nervous system. It is primarily found in Cytoplasm and contributes to normal cellular homeostasis, signaling, and neuronal function.
CYFIP2 is implicated in the following neurodegenerative conditions:
Misfolding, aggregation, or dysfunction of CYFIP2 contributes to neuronal damage through various mechanisms including proteotoxic stress, disrupted cellular signaling, and neuroinflammation.
CYFIP2 represents an important therapeutic target. Multiple drug development programs are exploring strategies to modulate its function, reduce toxic forms, or enhance clearance mechanisms.
Publication list pending enrichment from PubMed.
The study of Cyfip2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Page auto-generated from NeuroWiki protein database. Last updated: 2026-02-26.