Cst3 (Cystatin C) Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Cystatin C |
|---|---|
| Gene | CST3 |
| UniProt ID | P01034 |
| PDB ID | 1G96, 3LXB, 4N8M |
| Molecular Weight | 13.3 kDa |
| Subcellular Localization | Extracellular, Secreted |
| Protein Family | Cystatin family |
Cystatin C is a 13.3 kDa secreted cysteine protease inhibitor belonging to the type 2 cystatin family. The protein has a characteristic cystatin-like fold:
Cystatin C is a potent inhibitor of cysteine proteases including cathepsins B, H, L, and S:
Primary functions:
Expression:
Gauthier S, et al. (2011). "Cystatin C as a potential biomarker for Alzheimer's disease." Curr Alzheimer Res. 8(2):125-131.
Skerget K, et al. (2010). "Cystatin C and risk of dementia: a population-based study." Dement Geriatr Cogn Disord. 30(3):277-281.
Mathews PM, et al. (2000). "Cystatin C, a protective protein in neurodegeneration." Mol Neurobiol. 21(1-2):61-66.
The study of Cst3 (Cystatin C) Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
CST3 encodes Cystatin C, a cysteine protease inhibitor that plays important roles in protein regulation and has been implicated in Alzheimer's disease and cerebral amyloid angiopathy.