Cdr1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{Infobox protein}}
{{Infobox .infobox .infobox-protein|
| protein_name = CDR1AS (Cerebellar Degeneration-Related 1 Antisense)
| gene_name = CDR1 (CDR1AS)
| gene = CDR1
| UniProt ID = -
| PDB IDs = -
| molecular_weight = ~1.5 kb (circular RNA)
| localization = Cytoplasm, Synapses
| family = Circular RNA (circRNA)
}}
CDR1AS is a circular RNA (circRNA) derived from the CDR1 gene locus. It is a stable circular molecule formed by back-splicing. CDR1AS contains multiple binding sites for miR-7 and miR-876-5p.
CDR1AS functions as a competing endogenous RNA (ceRNA):
The study of Cdr1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The CDR1 Protein is involved in various cellular processes in the nervous system. This entity plays important roles in neuronal function, gene expression regulation, and cellular homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
The CDR1 Protein participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to synaptic transmission, gene regulation, and intracellular signaling cascades.
Alterations in CDR1 Protein expression or function have been associated with several neurodegenerative conditions. Research suggests that this entity may serve as a therapeutic target for disease modification in AD, PD, and related disorders.