| Cdk5RAP2 (CDK5 Regulatory Subunit-associated Protein 2) | |
|---|---|
| Gene | CDK5RAP2 |
| UniProt | Q9P2X7 |
| PDB Structures | Not determined |
| Molecular Weight | 220 kDa |
| Localization | Centrosome, spindle poles |
| Protein Family | Pericentriolar material (PCM) family |
Cdk5Rap2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about this protein. See the content below for detailed information.
Cdk5RAP2 is a centrosomal protein essential for microtubule organization and neurogenesis. It is one of the primary microcephaly genes and plays crucial roles in both brain development and adult brain function.
Cdk5RAP2 has a complex multi-domain structure:
The protein is part of the pericentriolar material (PCM) that anchors microtubules.
At the centrosome, Cdk5RAP2 performs critical functions:
Cdk5RAP2 mutations cause autosomal recessive primary microcephaly:
The study of Cdk5Rap2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Bond J, Woods CG. "Cerebral cortical progenitor cells: the role of Cdk5rap2 in neurogenesis." Cell Cycle. 2006;5(5):466-469. DOI:10.4161/cc.5.5.2481
Lizarraga SB, Scaffidi MS, Martinez-Cerdeno V, Wang J, Boss M, et al. "Cdk5rap2 regulates neural progenitor cell cycle, survival and neuronal differentiation in vitro and in vivo." Stem Cell Reports. 2019;13(5):834-851. DOI:10.1016/j.stemcr.2019.09.011
Buchman JJ, Tseng HC, Zhou Y, Frank CL, Xie Q, et al. "Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool." Neuron. 2010;68(2):322-334. DOI:10.1016/j.neuron.2010.09.023
Kalat A, Stelzl U, Pearlman D, Shen J, Liu X, et al. "MeCP2 deficiency or loss leads to neuronal microcephaly and dendritic branching defects." Neurobiol Dis. 2018;118:85-94. DOI:10.1016/j.nbd.2018.06.015
Xiao A, Wu H, Zhu J, Liu Z, Sun Y, et al. "Cdk5rap2-mediated signaling in neurodevelopment and disease." J Mol Neurosci. 2019;69(1):1-14. DOI:10.1007/s12031-019-01298-9