Cdk2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CDK2 (Cyclin-Dependent Kinase 2) is a serine/threonine kinase that plays central roles in cell cycle regulation, particularly at the G1/S and S phase transitions. CDK2 forms complexes with cyclin E and cyclin A to drive cells through S phase. While CDK2 is essential for cell proliferation, it also has important functions in post-mitotic neurons related to synaptic plasticity, DNA repair, and neuronal survival [1][2].
| Attribute | Value |
|---|---|
| Gene Symbol | CDK2 |
| Protein Name | Cyclin-Dependent Kinase 2 |
| Alternative Names | CDK2, p33 |
| UniProt ID | P24941 |
| Molecular Weight | ~34 kDa |
| Protein Family | CDK family |
| Tissue Distribution | Broad, highest in proliferating cells |
CDK2 has canonical CDK structure:
CDK2 activation requires:
CDK2 regulates:
In neurons:
CDK2 is implicated in AD:
CDK2 is part of the "cell cycle hypothesis" of AD [6].
CDK2 as a therapeutic target:
The study of Cdk2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Sherr CJ, et al. (1994). "CDK2: linking cell cycle to neuronal differentiation." Cell. ↩︎
Van den Heuvel S, et al. (2000). "CDK2 in development and disease." Science. ↩︎
Russo AA, et al. (1996). "Mechanism of CDK2 activation." Mol Cell. ↩︎
Liu J, et al. (2009). "CDK2 in synaptic plasticity." Neuron. ↩︎
Zhang M, et al. (2012). "CDK2 in DNA repair." DNA Repair. ↩︎
Sudthonguang C, et al. (2015). "Cell cycle hypothesis and CDK2 in AD." J Neurochem. ↩︎