Catalase Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Catalase Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Catalase |
|---|---|
| Gene | CAT |
| UniProt ID | P04040 |
| PDB ID | 1TGU, 1DBO, 4BLC |
| Molecular Weight | 59.7 kDa |
| Subcellular Localization | Peroxisomes |
| Protein Family | Catalase family |
Catalase is a 59.7 kDa tetrameric heme-containing enzyme. Each subunit (~60 kDa) contains:
The enzyme's structure includes:
Catalase is a key antioxidant enzyme that catalyzes the decomposition of hydrogen peroxide into water and oxygen:
Reaction: 2 H₂O₂ → 2 H₂O + O₂
This reaction occurs via a two-step mechanism:
Additional functions:
In neurons, catalase provides baseline protection against oxidative stress and is particularly important in regions with high metabolic activity.
Terman A, et al. (2006). "Catalase: extending the lifespan of cells." J Gerontol A Biol Sci Med Sci. 61(4):366-367.
Goh J, et al. (2012). "Catalase deficiency accelerates neuronal death in a mouse model of neuronal ceroid lipofuscinosis." Acta Neuropathol. 124(5):687-699.
Bai J, et al. (2019). "Catalase and neurodegeneration: what's the connection?" J Transl Med. 17(1):384.
Catalase Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Catalase Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.