Caml Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CAML (Calcium Modulator and Cyclophilin Ligand), also known as UNC93B1 or TMEM111, is a transmembrane protein involved in calcium signaling. It modulates store-operated calcium entry.
- Molecular weight: ~64 kDa
- Transmembrane domains: Multiple
- Cellular localization: Endoplasmic reticulum, plasma membrane
CAML:
- Calcium signaling: Regulates store-operated calcium entry
- Cell survival: Anti-apoptotic function
- Immune modulation: Modulates T-cell activation
- ER function: Maintains ER calcium stores
- ALS: CAML deficiency enhances motor neuron death
- Neuroinflammation: Modulates microglial activation
- Calcium channel modulators: Targeting CAML-regulated channels
- Neuroprotective strategies: Enhancing CAML function
- Brodmerkel et al., CAML function (2005)
- Matsuzaki et al., CAML in neurodegeneration (2018)
The study of Caml Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Neurodegenerative disease mechanisms and therapeutic approaches - Goedert M, et al. Science. 2019.
- Molecular basis of neurodegeneration in the central nervous system - Brettschneider J, et al. Nat Neurosci. 2018.
- Protein aggregation in neurodegenerative diseases: mechanisms and therapy - Sweeney P, et al. Nat Rev Dis Primers. 2017.
- Genetic susceptibility to neurodegenerative diseases - Gatz M, et al. Nat Rev Genet. 2006.
- Neuroinflammation in neurodegenerative disease - Heneka MT, et al. Lancet Neurol. 2015.
- Cellular and molecular mechanisms of neurodegeneration - Jellinger KA. J Neural Transm. 2018.
- Therapeutic strategies for neurodegenerative disorders - Schapira AHV, et al. Lancet Neurol. 2017.
- Biomarkers for neurodegenerative diseases - Zetterberg H, et al. Nat Rev Neurol. 2016.