Calmodulin 3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Calmodulin-3
| Protein Name | Calmodulin-3 |
| Gene Symbol | CALM3 |
| UniProt ID | P62158 |
| PDB ID | 1CLL |
| Molecular Weight | 16.7 kDa |
| Subcellular Localization | Cytoplasm, Nucleus |
| Protein Family | Calmodulin (EF-hand calcium-binding protein) |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cardiomyopathy, Myopathy |
Calmodulin-3 (CALM3 encoded) is a Calmodulin (EF-hand calcium-binding protein) that plays critical roles in Calcium sensor regulating target proteins in muscle and brain. This protein is implicated in the pathogenesis of several neurodegenerative diseases through its involvement in calcium signaling, muscle contraction, neuronal function.
Calmodulin-3 is encoded by a different gene but has an identical protein sequence to calmodulin-1 and -2.
Calmodulin-3 is highly expressed in skeletal muscle and heart, where it regulates excitation-contraction coupling.
Calmodulin-3 in muscle tissue may be relevant for understanding myopathic complications.
| Disease | Pathogenic Mechanism |
|---|---|
| Alzheimer's Disease | Pathogenic variants |
| Parkinson's Disease | Pathogenic variants |
| Cardiomyopathy | Pathogenic variants |
| Myopathy | Pathogenic variants |
Cardiac and skeletal muscle function depend on proper calmodulin-3 signaling.
Muscle-directed therapies may consider calmodulin-3 function.
The study of Calmodulin 3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.