Calcineurin A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Calcineurin A (Protein Phosphatase 3) | |
|---|---|
| Protein Name | Calcineurin A |
| Gene | PPP3CA |
| UniProt ID | P26448 |
| PDB ID | 1TCO, 2JDI |
| Molecular Weight | 59 kDa (catalytic subunit) |
| Subcellular Localization | Cytoplasm |
| Protein Family | PP2B family, Ser/Thr protein phosphatase |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis |
Calcineurin is a heterodimer of:
The A subunit contains:
Calcineurin is uniquely activated by sustained calcium elevation (unlike other calmodulin-dependent enzymes).
Calcineurin regulates critical neuronal functions:
In Alzheimer's Disease:
In Parkinson's Disease:
In ALS:
Calcineurin is a major drug target:
The study of Calcineurin A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This section provides background information on the gene/protein and its role in the nervous system.
This overview section needs to be expanded with relevant scientific information from peer-reviewed sources.