Btrc Protein is involved in cellular processes relevant to neurodegeneration. For detailed information, refer to the References section.
BTRC (β-TrCP) is an F-box protein that recognizes phosphorylated substrates and targets them for ubiquitination. It is part of the SCF ubiquitin ligase complex and regulates the circadian clock and other pathways. [1]
| Protein Name | F-Box/WD Repeat-Containing Protein 1 (β-TrCP1) |
|---|---|
| Gene | [BTRC](/genes/btrc) |
| UniProt ID | [Q9Y297](https://www.uniprot.org/uniprot/Q9Y297) |
| PDB Structure IDs | 1P22, 1QQU |
| Molecular Weight | 68 kDa |
| Subcellular Localization | Cytoplasm |
| Protein Family | F-box protein family |
BTRC contains an F-box domain at the N-terminus for Skp1 binding and a C-terminal WD40 repeat domain for substrate recognition. The WD40 domain recognizes phosphorylated substrates with a DSGxxS motif.
β-TrCP is an F-box protein that is part of the SCF (Skp1-Cullin1-F-box) ubiquitin ligase complex. It recognizes phosphorylated substrates and targets them for proteasomal degradation.
Key substrates include:
β-TrCP therefore links protein phosphorylation to ubiquitination and degradation, regulating circadian rhythms, NF-κB signaling, and Wnt signaling.
Alzheimer Disease: β-TrCP may affect amyloid and tau metabolism through regulation of protein degradation pathways. Its expression is altered in AD.
Parkinson Disease: β-TrCP may be involved in α-synuclein degradation. Altered expression is observed in PD models.
Cancer: β-TrCP is an oncogene overexpressed in several cancers. It targets tumor suppressors including IκBα and β-catenin for degradation.
Inflammatory Disease: β-TrCP regulates NF-κB signaling and is implicated in inflammatory disorders.
β-TrCP is a challenging drug target due to its protein-protein interaction interface. Research directions include:
[Karin and Ben-Neriah, Beta-TrCP and ubiquitination (2000)](https://doi.org/10.1016/S0092-8674(00). 2000. ↩︎