| ATP5F1 Protein — ATP Synthase F1 Subunit Beta | |
|---|---|
| Gene | ATP5F1 |
| UniProt | P06576 |
| PDB | 6CP6 |
| Mol. Weight | 51 kDa |
| Localization | Mitochondrial inner membrane (Complex V) |
| Family | ATP synthase F1 family |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Mitochondrial Disorders |
ATP5F1 encodes the beta subunit of the F1 sector of mitochondrial ATP synthase (Complex V), the enzyme responsible for synthesizing ATP from ADP using the proton gradient generated by the electron transport chain[1]. ATP5F1 is crucial for cellular energy production, and its dysfunction is a hallmark of neurodegenerative diseases including Alzheimer's Disease and Parkinson's Disease[2].
ATP5F1 is the catalytic core of the ATP synthase complex. The F1 sector contains three alpha and three beta subunits, with the beta subunits providing the catalytic sites for ATP synthesis[3].
The ATP synthase (Complex V) consists of:
ATP5F1 features:
Nature reviews. Mitochondrial DNA repair and neurodegeneration. Nature Reviews Neuroscience. 2010;11(5):301-315. ↩︎
DiMauro S, Schon EA. Mitochondrial respiratory-chain diseases. New England Journal of Medicine. 2003;348(26):2656-2668. ↩︎
Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006;443(7113):787-795. ↩︎