Atlastin 1 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Atlastin 1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{Infobox .infobox .infobox-protein
| protein_name = Atlastin-1 Protein
| gene = ATL1
| uniprot_id = Q9Y2H5
| molecular_weight = ~56 kDa
| localization = Endoplasmic reticulum membrane
| family = Atlastin family, GTPase
}}
ATL1 (Atlastin-1) is a membrane-bound GTPase involved in ER network formation.
- N-terminal GTPase domain
- Transmembrane regions (3)
- C-terminal helical domain
- ER network formation and maintenance
- Membrane fusion
- Axon guidance
- Synapse development
- Hereditary spastic paraplegia (SPG3A): ATL1 mutations cause pure and complex HSP
- Involved in axonal transport
- ER stress response
Atlastin 1 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Atlastin 1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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