Atg4C Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Atg4C Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| ATG4C Protein | |
|---|---|
| Protein Name | Autophagy Related 4C Cysteine Peptidase |
| Gene | ATG4C |
| UniProt ID | Q9Y4P5 |
| PDB Structure | 2P0N, 2P4L |
| Molecular Weight | 52 kDa |
| Subcellular Localization | Cytoplasm |
| Protein Family | Cysteine Protease, ATG4 Family |
ATG4C is a 476-amino acid cysteine protease belonging to the ATG4 family (ATG4A-D). It contains a catalytic cysteine protease domain with the conserved catalytic triad (Cys-His-Asp). The protease domain is flanked by N- and C-terminal regulatory regions that control substrate access and subcellular localization.
ATG4C processes LC3 (MAP1LC3A/B) and other Atg8 family proteins. It cleaves the C-terminal glycine from pro-LC3 to generate LC3-I, which is then conjugated to phosphatidylethanolamine to form LC3-II, the lipidated form that associates with autophagosomal membranes. ATG4C is involved in both basal and induced autophagy.
| Disease | Mechanism | Evidence |
|---|---|---|
| Parkinson's Disease | Impaired autophagy leads to accumulation of protein aggregates. | Genetic studies |
| Huntington's Disease | Altered protein clearance contributes to mutant huntingtin accumulation. | Mouse models |
| Cancer | Autophagy regulation affects tumor survival. | Clinical studies |
| Cardiomyopathy | Autophagy defects cause cardiac dysfunction. | Animal models |
Atg4C Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Atg4C Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.