APEX2 is a paralog of APEX1 with both nuclear and mitochondrial localization. It participates in DNA repair in both compartments. APEX2 is important for mitochondrial DNA maintenance and neuronal survival.
| Attribute | Value |
|---|---|
| Protein Name | DNA Apurinic/Apyrimidinic Endonuclease 2 |
| Gene | APEX2 |
| UniProt ID | Q9Y2E5 |
| PDB ID | N/A |
| Molecular Weight | 57 kDa |
| Subcellular Localization | Nucleus, Mitochondria |
| Protein Family | Exonuclease III family |
DNA Apurinic/Apyrimidinic Endonuclease 2 is a Exonuclease III family protein involved in various cellular processes in the nervous system.
APEX2 is a paralog of APEX1 with both nuclear and mitochondrial localization. It participates in DNA repair in both compartments. APEX2 is important for mitochondrial DNA maintenance and neuronal survival.
APEX2 deficiency may lead to increased DNA damage and neurodegeneration.
DNA repair enhancers are being investigated for neurodegenerative conditions.