Apbb1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| APBB1 (Fe65) Protein | |
|---|---|
| Protein Name | Amyloid precursor protein-binding family B member 1 |
| Alternative Names | Fe65, RIR |
| UniProt ID | Q9UKP3 |
| Gene Symbol | APBB1 |
| Protein Type | Adaptor protein |
| Molecular Weight | ~90 kDa (825 aa) |
| Cellular Location | Cytoplasm, Nucleus, Plasma membrane |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
APBB1 contains three distinct protein-protein interaction domains:
APBB1 serves as a molecular adaptor linking APP to multiple signaling pathways:
| Partner | Interaction Type | Functional Significance |
|---|---|---|
| APP | Direct binding | APP processing |
| BACE1 | Indirect | Amyloid production |
| Tau | Direct binding | Phosphorylation |
| TIP60 | Coactivator | Transcription |
| histone acetyltransferases | Complex | Epigenetic regulation |
Dysregulation of APBB1 contributes to:
The study of Apbb1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.