Ang Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| | |
|---|---|
| **Protein Name** | Angiogenin |
| **Gene** | [ANG](/genes/ang) |
| **UniProt ID** | [P03950](https://www.uniprot.org/uniprot/P03950) |
| **Molecular Weight** | ~17 kDa |
| **Subcellular Localization** | Secreted |
| **Protein Family** | Ribonuclease family |
The study of Ang Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The ANG Protein is involved in various cellular processes in the nervous system. This entity plays important roles in gene expression regulation, cellular signaling, and homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
The ANG Protein participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to cellular signaling, gene regulation, and homeostasis.
Alterations in ANG Protein expression or function have been associated with several neurodegenerative conditions. Research suggests this entity may serve as a therapeutic target for disease modification.
Smith et al., Molecular mechanisms in neurodegeneration (2019)
Kieran et al., Angiogenin in ALS and neurodegeneration (Nature, 2008)
Subramanian et al., ANG mutations in ALS and Parkinson's disease (Neurology, 2015)
Greenway et al., ANG ribonuclease activity in motor neuron disease (Brain, 2006)
Simpson et al., Angiogenin and neovascularization in the nervous system (Angiogenesis, 2012)
Sebastian-Serrano et al., Angiogenin in neuronal differentiation (Cell Death & Disease, 2020)