Synaptophysin Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SYP is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of SYP is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
Protein Name: Synaptophysin (p38)
Gene: SYP
UniProt ID: P08240
Molecular Weight: 38 kDa
Subcellular Localization: Synaptic vesicle membrane
Protein Family: Synaptophysin Family
Synaptophysin has a characteristic architecture:
The protein is heavily glycosylated in its luminal domains[1].
Synaptophysin is essential for synaptic vesicles:
SYP modulates synaptic transmission:
Widely used as presynaptic marker:
Synaptophysin loss in AD:
In PD:
SYP as a biomarker:
Targeting synaptic dysfunction:
Navone F, et al. (1986). "Synaptophysin: a synaptic vesicle glycoprotein throughout the nervous system." J Exp Med. 164(1):141-158. [DOI:10.1084/jem.164.1.141^1]
Valtorta F, et al. (2004). "Synaptophysin: leading actor or walk-on in the control of neurotransmission?" Brain Res Rev. 45(2):119-131. [DOI:10.1016/j.brainresrev.2004.02.008^2]
Masliah E, et al. (1990). "Synaptic and neuritic alterations during the progression of Alzheimer's disease." Neurosci Lett. 118(2):173-176. DOI:10.1016/0304-3940(9090620-C[3:1]
The study of Synaptophysin Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Navone F, et al. (1986). "Synaptophysin: a synaptic vesicle glycoprotein throughout the nervous system." J Exp Med. 164(1):141-158. DOI:10.1084/jem.164.1.141 ↩︎
Valtorta F, et al. (2004). "Synaptophysin: leading actor or walk-on in the control of neurotransmission?" Brain Res Rev. 45(2):119-131. DOI:10.1016/j.brainresrev.2004.02.008 ↩︎
Masliah E, et al. (1990). "Synaptic and neuritic alterations during the progression of Alzheimer's disease." Neurosci Lett. 118(2):173-176. DOI:10.1016/0304-3940(9090620-C ↩︎ ↩︎