Atr Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| ATR Protein |
|---|
| Protein Name | ATM and Rad3-Related |
| Gene | ATR |
| UniProt ID | Q13535 |
| PDB IDs | 5OPI, 6DUS |
| Molecular Weight | 300 kDa |
| Subcellular Localization | Nucleus (activated at stalled forks) |
| Protein Family | PI3/PI4-related protein kinases |
ATR PROTEIN is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of ATR PROTEIN is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
ATR is a large serine/threonine kinase:
- ATRIP binding domain: Interacts with ATRIP
- PI3K-like kinase domain: Catalytic activity
- FATC domain: Required for function
- Helicase domain: DNA binding
- Replication stress response: Primary sensor for stalled forks
- S-phase checkpoint: Prevents replication collapse
- DNA repair: Coordinates repair of lesions
- Chromatin remodeling: Modifies chromatin state
- Transcription effects: Global transcriptional changes
- Altered ATR signaling in ALS
- Replication stress in motor neurons
- Replication stress in neurons
- ATR activation in AD brain
- Genotoxic stress in dopaminergic neurons
- 11376233: ATR in replication stress. EMBO J, 2001.
- 28714940: DNA damage in neurodegeneration. Nat Rev Neurol, 2017.
The study of Atr Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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