Vamp1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | VAMP1 |
|---|---|
| Gene Name | Vesicle Associated Membrane Protein 1 (Synaptobrevin 1) |
| Chromosome | 12p13.31 |
| NCBI Gene ID | 6843 |
| OMIM ID | 185880 |
| Ensembl ID | ENSG00000139190 |
| UniProt ID | P61227 |
| Associated Diseases | Spinal Muscular Atrophy, Myasthenia Gravis, Epilepsy |
| --- | --- |
| Categories | Synaptic Transmission, SNARE Complex |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
VAMP1 (synaptobrevin 1) is a synaptic vesicle protein essential for neurotransmitter release. It is a v-SNARE that forms the SNARE complex with syntaxin and SNAP-25 to mediate vesicle fusion. VAMP1 is primarily expressed in the brain and spinal cord. Mutations cause severe neuromuscular disorders including spinal muscular atrophy with myasthenic symptoms.
The VAMP1 gene is associated with several diseases.
The study of Vamp1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.