Stx1B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | STX1B |
|---|---|
| Gene Name | Syntaxin 1B |
| Chromosome | 16p11.2 |
| NCBI Gene ID | 11267 |
| OMIM ID | 195005 |
| Ensembl ID | ENSG00000099365 |
| UniProt ID | P61264 |
| Associated Diseases | Epilepsy, Ataxia, Intellectual Disability |
| --- | --- |
| Categories | Synaptic Transmission, SNARE Complex |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
Syntaxin 1B is a presynaptic plasma membrane protein involved in synaptic vesicle docking and fusion. It is a member of the SNARE (Soluble NSF Attachment Protein Receptor) complex and interacts with SNAP-25 and VAMP/synaptobrevin to mediate neurotransmitter release. STX1B mutations cause familial epilepsy and ataxia, highlighting its critical role in synaptic transmission.
The STX1B gene is associated with several diseases.
The study of Stx1B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.