Snap25 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SNAP25 is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of SNAP25 is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
Symbol: SNAP25
Full Name: Synaptosomal-Associated Protein 25
Chromosomal Location: 20p12.3
NCBI Gene ID: 6617
Ensembl ID: ENSG00000132639
UniProt ID: P60880
OMIM: 600014
SNAP-25 is a core component of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) complex essential for synaptic vesicle fusion and neurotransmitter release[1].
SNAP-25 forms the ternary SNARE complex:
This 4-helix bundle drives membrane fusion.
SNAP-25 is crucial for exocytosis:
SNAP25 has multiple isoforms:
SNAP25 changes in AD:
In PD:
SNAP25 in seizure disorders:
SNAP25 in schizophrenia:
SNAP25 is target of botulinum toxins:
SNAP25 is expressed in:
High expression in cortex, hippocampus, basal ganglia, and brainstem.
Targeting SNAP25:
SNAP25 as marker:
Söllner T, et al. (1993). "SNAP receptors implicated in vesicle targeting and fusion." Nature. 362(6418):318-324. [DOI:10.1038/362318a0^1]
Bark C, et al. (1995). "Differential expression of SNAP-25 protein isoforms in the developing rat brain." J Comp Neurol. 361(2):194-201. [DOI:10.1002/cne.903610203^2]
Shimohama S, et al. (1998). "Alterations of the SNARE complex in rat brain." J Neurosci Res. 53(4):519-525. DOI:10.1002/(SICI1097-4547(19980815)53:4<519::AID-JNR14>3.0.CO;2-5[3:1]
The study of Snap25 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Söllner T, et al. (1993). "SNAP receptors implicated in vesicle targeting and fusion." Nature. 362(6418):318-324. DOI:10.1038/362318a0 ↩︎
Bark C, et al. (1995). "Differential expression of SNAP-25 protein isoforms in the developing rat brain." J Comp Neurol. 361(2):194-201. DOI:10.1002/cne.903610203 ↩︎
Shimohama S, et al. (1998). "Alterations of the SNARE complex in rat brain." J Neurosci Res. 53(4):519-525. DOI:10.1002/(SICI1097-4547(19980815)53:4<519::AID-JNR14>3.0.CO;2-5 ↩︎ ↩︎