Ppp3Ca Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | PPP3CA |
|---|---|
| Gene Name | Protein Phosphatase 3 Catalytic Subunit Alpha (Calcineurin A) |
| Chromosome | 4p16.3 |
| NCBI Gene ID | 5530 |
| OMIM ID | 114105 |
| Ensembl ID | ENSG00000138814 |
| UniProt ID | P48455 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Immunosuppression |
| --- | --- |
| Categories | Calcium Signaling, Synaptic Plasticity |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
PPP3CA encodes the catalytic subunit of calcineurin, a calcium/calmodulin-dependent phosphatase essential for T-cell activation and neuronal signaling. Calcineurin dephosphorylates NFAT transcription factors, regulating gene expression in immune cells and neurons. In the brain, calcineurin modulates synaptic plasticity and memory. Its activity is altered in Alzheimer's disease.
The PPP3CA gene is associated with several diseases.
The study of Ppp3Ca Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.