Ngfr Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | NGFR |
|---|---|
| Gene Name | Nerve Growth Factor Receptor (p75NTR) |
| Chromosome | 17q21.22 |
| NCBI Gene ID | 4804 |
| OMIM ID | 162010 |
| Ensembl ID | ENSG00000064300 |
| UniProt ID | P08183 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Hirschsprung Disease |
| --- | --- |
| Categories | Neurotrophin Signaling, Neuroprotection |
The nerve growth factor receptor (NGFR), also known as p75NTR, is a member of the tumor necrosis factor receptor superfamily. It serves as a key modulator of neurotrophin signaling, influencing neuronal survival, differentiation, and apoptosis. NGFR is widely expressed in the nervous system and plays critical roles in development, maintenance, and disease.
The nerve growth factor receptor (NGFR), also known as p75NTR, is a transmembrane receptor that binds NGF and other neurotrophins. Unlike Trk receptors, p75NTR can signal for both cell survival and apoptosis depending on context and co-receptor expression. It interacts with both TrkA and sortilin to modulate neurotrophin signaling, and plays roles in neuronal development, myelination, and neuroinflammation. Genetic variants in NGFR are associated with increased risk for Alzheimer's and Parkinson's diseases.
The NGFR gene is associated with several neurodegenerative and neurological disorders. Specific mutations cause distinct clinical phenotypes, and common variants may influence disease risk.
The study of Ngfr Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.