Homer1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | HOMER1 |
|---|---|
| Gene Name | Homer Scaffold Protein 1 |
| Chromosome | 5q33.2 |
| NCBI Gene ID | 9456 |
| OMIM ID | 604798 |
| Ensembl ID | ENSG00000152413 |
| UniProt ID | Q9NYB8 |
| Associated Diseases | Schizophrenia, Alzheimer's Disease, Addiction |
| --- | --- |
| Categories | Calcium Signaling, Synaptic Plasticity |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
Homer 1 is a postsynaptic scaffold protein that binds to group I metabotropic glutamate receptors (mGluR1/5) and regulates calcium signaling. It links mGluRs to downstream effectors and the actin cytoskeleton. HOMER1 is implicated in synaptic plasticity, drug addiction, and neuropsychiatric disorders including schizophrenia.
The HOMER1 gene is associated with several diseases.
The study of Homer1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.