Grip1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | GRIP1 |
|---|---|
| Gene Name | Glutamate Receptor Interacting Protein 1 |
| Chromosome | 12q14.3 |
| NCBI Gene ID | 23426 |
| OMIM ID | 604597 |
| Ensembl ID | ENSG00000155966 |
| UniProt ID | Q9Y2R0 |
| Associated Diseases | Autism Spectrum Disorder, Intellectual Disability, Friedreich's Ataxia |
| --- | --- |
| Categories | Calcium Signaling, Synaptic Plasticity |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
GRIP1 is a PDZ domain-containing scaffold protein that binds to AMPA receptor subunits and regulates their trafficking. It interacts with GRIP-associated proteins and is important for synaptic plasticity. GRIP1 mutations cause autosomal recessive Friedreich's ataxia-like disorders and are implicated in autism.
The GRIP1 gene is associated with several diseases.
The study of Grip1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.